Journal of Traditional and Complementary Medicine, 2(4), 331-339.
| Side Effect | Common Causes | Severity | Recommended Action |
|---|---|---|---|
| Headache | Excessive dosage | Mild to Moderate | Reduce dose, consult doctor |
| Digestive upset | Certain herbs or ingredients | Mild | Take with food |
| Allergic reactions | Hyaluronic acid or plant extracts | Mild to severe | Discontinue use, see doctor |
| Dizziness | Blood flow related effects | Mild | Rest, hydrate |
Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial. Menopause (New York, N.Y.), 23(11), 1252–1256. A systematic review of clinical trials on Ginkgo (Ginkgo biloba) effectiveness on sexual function and its safety. Journal of ethnopharmacology, 145(3), 715–721. Capsaicinoids Modulating Cardiometabolic Syndrome Risk Factors: Current Perspectives. The effect of melatonin on the sexual function among postmenopausal women: A randomized placebo-controlled trial. Nursing and Midwifery Studies, 6(4), 149.
Understanding Unapproved Use of Approved Drugs "Off Label".
Innerbody uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Clayton, A. H., Goldstein, I., Kim, N. N., Althof, S.
E., Faubion, S. S., Faught, B. M., Parish, S. J., Simon, J. The International Society for the Study of Women's Sexual Health Process of Care for Management of Hypoactive Sexual Desire Disorder in Women.
Mayo Clinic Proceedings, 93(4), 467–487. Female sexual dysfunction (FSD): Prevalence and impact on quality of life (QoL). Mayo Foundation for Medical Education and Research (MFMER). Icahn School of Medicine at Mount Sinai. 197 A Double-blind, Placebo-controlled, 2-Way Crossover Study Using Thermography to Assess the Pharmacodynamics of Sildenafil Cream, 3.6% in Healthy Women. Physiologic Measures of Sexual Function in Women: A Review. Topical Pentoxifylline for Pressure Injury Prevention: A Call for Clinical Research.
| Product | Dosage | Quantity + Bonus | Price | |
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| Levitra Generic | 40mg | 30 + 2 Pills | 93.58€ 89.12€ | |
| Cialis Generic | 20mg | 180 + 10 Pills | 254.09€ 241.99€ | |
| Kamagra Oral Jelly | 100mg | 63 + 7 Sachets | 224.18€ 213.50€ | |
| Viagra Generic | 25mg | 20 Pills | 37.74€ 35.94€ | |
| Cialis Generic | 60mg | 180 + 10 Pills | 313.11€ 298.20€ | |
| Cialis Generic | 40mg | 270 + 10 Pills | 382.19€ 363.99€ | |
| Viagra Professional | 100mg | 90 + 2 Pills | 207.09€ 197.23€ | |
| Super Kamagra | 160 mg | 4 Pills | 41.99€ 39.99€ | |
| Kamagra Oral Jelly | 100mg | 30 + 5 Sachets | 136.20€ 129.71€ | |
| Cialis Super Active | 20mg | 90 + 10 Pills | 314.14€ 299.18€ | |
| Kamagra Soft Tabs | 100mg | 60 + 4 Pills | 180.59€ 171.99€ | |
| Viagra Generic | 150mg | 60 + 4 Pills | 111.25€ 105.95€ |
Advances in skin & Wound Care, 32(11), 486. The effect of topically applied vasoactive agents and testosterone versus testosterone in the treatment of erectile dysfunction in aged men with low sexual interest. International Journal of Impotence Research, 13(2), 93–99. Chemical composition, olfactory evaluation and antioxidant effects of essential oil from Mentha x piperita. Natural Product Communications, 4(8), 1107–1112. Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers.
Clinical trials show a positive impact on HSDD Convenient telehealth consultation and free prescription shipping Financial assistance available for qualifying individuals without insurance There is no restriction on drinking alcohol while using Vyleesi You can get a prescription online through manufacturer’s telemed partner, Prescribery Medication is shipped to you for free from BlinkRx specialty pharmacy Each prescription fill only contains four doses A long list of possible side effects Not for those who have already gone through menopause Not recommended for those with high blood pressure or cardiovascular concerns Can be extremely expensive if you are uninsured and don’t qualify for assistance Vyleesi (bremelanotide) is an FDA-approved injectable prescription medication that can be used as needed to treat Hypoactive Sexual Desire Disorder (HSDD) in premenopausal women. HSDD is defined as a “persistent or recurrent absence of sexual fantasies and desire for sexual activity” that leads to distress or relationship difficulties. It’s not caused by a medical or mental health issue, relationship problem, or drug use. Essentially, you know you have HSDD if your libido used to be acceptable to you, but it’s recently taken a dip, and this lower libido is causing you distress.18 54 Clinical trials investigating the effectiveness of Vyleesi for the treatment of HSDD have shown promising results. Versus a placebo, researchers reported that Vyleesi “significantly increased sexual desire.”56 To take Vyleesi, you use the autoinjector pen to give yourself an injection under the skin on your thighs or stomach about 45 minutes before sexual activity.
The manufacturer notes that it shouldn’t be used more than once per day or more than eight times per month. The active ingredient in Vyleesi is bremelanotide, an FDA-approved drug to treat HSDD. It’s important to note that this medication does bring about the possibility of side effects, including (but not limited to):7 Because Vyleesi can alter your heart rate and blood pressure, it isn’t recommended for people with hypertension or cardiovascular issues. Even if you don’t have those concerns, it’s important to speak with your primary care provider to ensure Vyleesi is safe for you. You can obtain a Vyleesi prescription either through your doctor or the manufacturer’s third-party telehealth partner, Prescribery, for a $29 consultation fee (just click the “Get Vyleesi Online” button on the top of the Vyleesi website).
No matter where you receive your prescription from, it will be shipped to you for free from BlinkRx, a specialty pharmacy. If you have insurance, the cost of Vyleesi may be covered. It’s a good idea to check with your plan beforehand to verify. If you don’t have insurance, Vyleesi offers financial assistance through an application on the prescription information website. You need to be at least 18 years old and not insured by a government agency (such as Medicaid) to be eligible for financial aid. Clitoral blood flow after use of gel containing L-arginine and L-citrulline. Turnera diffusa Wild (Turneraceae) recovers sexual behavior in sexually exhausted males. Journal of Ethnopharmacology, 123(3), 423–429. Hypoactive Sexual Desire Disorder: International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel Review. Mayo Clinic Proceedings, 92(1), 114–128. Flibanserin for Premenopausal Hypoactive Sexual Desire Disorder: Pooled Analysis of Clinical Trials. Journal of Women's Health (2002), 28(6), 769–777. Melanocortin 4 receptor agonism enhances sexual brain processing in women with hypoactive sexual desire disorder. Peripheral Female Genital Arousal as Assessed by Thermography Following Topical Genital Application of Alprostadil vs Placebo Arousal Gel: A Proof-of-Principle Study Without Visual Sexual Stimulation. Effect of Diindolylmethane on Estrogen-related Hormones, Metabolites and Tamoxifen Metabolism: Results of a Randomized, Placebo-controlled Trial. Cancer Epidemiology Biomarkers & Prevention 1, 26(3), 435. Flibanserin (Addyi): The First FDA-Approved Treatment for Female Sexual Interest/Arousal Disorder in Premenopausal Women.
| Medication Type | Possible Interaction | Effect | Recommendation |
|---|---|---|---|
| Blood pressure medications | Increased blood flow effects | Dizziness or hypotension | Consult doctor before use |
| Antidepressants | Reduced efficacy of tablets or side effects | Reduced libido, serotonin syndrome | Check with healthcare provider |
| Hormonal therapies | Altered hormone levels | Changes in libido or mood | Medical consultation needed |
| Blood thinners | Increased bleeding risk | Excessive bleeding | Medical advice required |
Role of Nitric Oxide in the Cardiovascular and Renal Systems. International Journal of Molecular Sciences, 19(9), 2605. Systematic review and meta-analysis of phosphodiesterase type 5 inhibitors for the treatment of female sexual dysfunction. International Journal of Gynecology & Obstetrics, 133(2), 139-145. Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial. (308) Oxytocin Troches as an Adjunctive Intervention to Conventional Testosterone and Erectile Dysfunction Medication for Men with Sexuality Concerns. The Journal of Sexual Medicine, 20(Supplement_1).
| Country | Regulations for Sexual Tablets | Ingredients Restrictions | Certification Requirements |
|---|---|---|---|
| USA | FDA approval recommended | Some herbs restricted | FDA approval or clear labeling |
| EU | CE marking required | Limited herbal stimulants | CE certification required |
| Australia | Therapeutic Goods Administration | Banned substances list | TGA registration required |
| Canada | Health Canada's approval | Strict ingredient standards | Approved formulations |
Tadalafil once daily: Narrative review of a treatment option for female sexual dysfunctions (FSD) in midlife and older women. Tadalafil reversal of sexual dysfunction caused by serotonin enhancing medications in women. Journal of Sex & Marital Therapy, 32(1), 1–3. Tadalafil 5 mg Daily Treatment for Type 1 Diabetic Premenopausal Women Affected by Sexual Genital Arousal Disorder. The Journal of Sexual Medicine, 9(8), 2057-2065. Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study.
The Journal of Sexual Medicine, 17(1), S69. Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women. Pharmacy: Journal of Pharmacy Education and Practice, 9(2). Vyleesi Prices, Coupons and Patient Assistance Programs. Endothelial Nitric Oxide Synthase Regulation in Female Genital Tract Structures.
The Journal of Sexual Medicine, 6, 247-253. Yes, you can have better sex in midlife and in the years beyond. Testosterone therapy in women: Does it boost sex drive? Treatment of Hypoactive Sexual Desire Disorder Among Women: General Considerations and Pharmacological Options. Focus: Journal of Life Long Learning in Psychiatry, 19(1), 39-45.
Integrative Medicine (Fourth Edition), 592-599.e2. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Effects of nine weeks L-Carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress in resistance-trained males. Journal of Exercise Nutrition & Biochemistry, 22(4), 7-19. Topics in Current Chemistry, 328, 155–240. Safety and influence of a novel extract of fenugreek on healthy young women: A randomized, double-blinded, placebo-controlled study. Evaluation of aphrodisiac activity of ethanol extract of Ganoderma lucidum in male Wistar rats. Translational Andrology and Urology, 11(7), 982. Guaraná's Journey from Regional Tonic to Aphrodisiac and Global Energy Drink.
Evidence-Based Complementary and Alternative Medicine: ECAM, 7(3), 279.
Seminal plasma magnesium and premature ejaculation: a case-control study. The Role of Magnesium in Hypertension and Cardiovascular Disease. The Journal of Clinical Hypertension, 13(11), 843-847. Effect of Zinc on Testosterone Levels and Sexual Function of Postmenopausal Women: A Randomized Controlled Trial. Journal of Sex & Marital Therapy, 47(8), 804–813.
BIOCHEMISTRY OF MOBILE ZINC AND NITRIC OXIDE REVEALED BY FLUORESCENT SENSORS. Adverse Events Associated with Melatonin for the Treatment of Primary or premature ejaculation medicine Secondary Sleep Disorders: A Systematic Review. Evaluation of Dietary Niacin and New-Onset Hypertension Among Chinese Adults. Hop extracts and hop substances in treatment of menopausal complaints. Hops for Menopausal Vasomotor Symptoms: Mechanisms of Action.