Clinical Indications for Sildenafil Citrate Beyond Erectile Dysfunction
Keep sildenafil out of the reach of children. If you keep sildenafil oral liquid in a refrigerator, make sure to keep it away from children who also use the refrigerator. Sexual activity can put extra strain on your heart, which may be unsafe for people with certain health problems, such as a recent heart attack. Talk to your healthcare provider to see if your heart is strong enough for sex.
Brand names
Ballard et al (1998) Effects of silde. Turko et al (1999) Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by silde. Ghofrani et al (2006) Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Smith-Berdan et al (2019) Viagra enables efficient, single-day hematopoietic stem cell mobilization. If you know of a relevant reference for Sildenafil citrate, please let us know.
Sildenafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Keywords: Sildenafil citrate, Sildenafil citrate supplier, phosphodiesterases, 5, PDE5, inhibitors, inhibits, orally, active, potent, HSC, hematopoietic, haematopoietic, stem, cells, mobilization, COVID-19, pulmonary, edema, Phosphodiesterases, Stem, Cell, Proliferation, Hematopoietic, Cells, 3784, Tocris Bioscience Citations are publications that use Tocris products. Vandendriessche et al (2013) The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems. Xiaofeng et al (2021) Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage. Cell Chem Biol 28 1669-1678.e5 PMID: 34166610 Do you know of a great paper that uses Sildenafil citrate from Tocris? There are currently no reviews for this product. If you feel chest pain, dizziness, or nausea during sex, stop and contact your healthcare provider right away.
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Sildenafil does not protect against sexually transmitted infections, including HIV. Sildenafil belongs to a group of medicines, known as phosphodiesterase-5 (PDE-5) inhibitors, which are used to treat erectile dysfunction or pulmonary arterial hypertension. You should not take more than one PDE-5 inhibitor medicine. Medicines in this group include avanafil (Stendra), sildenafil (Viagra, Revatio, and others), tadalafil (Cialis and others), and vardenafil (Levitra, Staxyn). Use an accurate measuring device to measure your dose of sildenafil oral liquid. A household spoon is not an accurate measuring device and may cause you to take the wrong dose.
Pregnancy & Lactation
If you take sildenafil after you eat a high-fat meal, such as a burger and fries, it may take longer to start working. Your healthcare provider may recommend limiting or avoiding grapefruit while taking sildenafil. Grapefruit or grapefruit juice can raise sildenafil levels in your body, which can increase the risk of side effects. There are no known interactions between sildenafil and alcohol. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
What dose should be taken?
In particular, make sure that you discuss if you are using any of the following before taking sildenafil. Tell your healthcare provider about all medicines that you take or have recently taken. This may not be a complete list of medicines that can interact with sildenafil. If you or someone else has used too much sildenafil, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222. For this use, sildenafil is used only when needed. Ask your pharmacist to recommend an appropriate measuring device.
- Sildenafil citrate can also treat pulmonary arterial hypertension.
- It enhances exercise capacity in patients with this condition.
- The drug’s effects usually last 4-6 hours.
- Taking it with a high-fat meal can delay absorption.
- Sildenafil should not be used with nitrate medications.
- Serious side effects include vision changes and priapism.
- It is contraindicated in individuals with certain heart conditions.
- Patients should inform their doctor about all medications.
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
| Property | Description | Value | Notes |
|---|---|---|---|
| Molecular Formula | - | C22H30N6O4S | Chemical composition |
| Molecular Weight | - | 474.6 g/mol | Molar mass |
| Melting Point | - | 195-198°C | Crystalline form |
| Solubility in Water | - | Slightly soluble | At room temperature |
| pH of Aqueous Solution | - | 3.5 - 4.0 | Depends on concentration |
This will help them determine if sildenafil is right for you. In particular, make sure that you discuss any of the following.
Other uses for this medicine
Take it as your healthcare provider recommends, which is usually between 30 minutes to four hours before planned sexual activity. For this use, take sildenafil as your healthcare provider recommends, which is usually three times a day. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Ask your healthcare provider if you are unsure what to do after a missed dose.
What is Sildenafil Citrate used for?
This survey is being conducted by the WebMD marketing sciences department. You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Sildenafil citrate promotes mobilization of hematopoietic stem cells (HSCs) in combination with AMD 3100 (Cat. Tell your healthcare provider if you have any of the following. Heart problems, such as heart rhythm problems, chest pain, or heart failure Heart attack, stroke, or heart surgery within the past six months High blood pressure that is still too high despite taking medicines for it Peyronie's disease, or a penis with an abnormal curve or shape An erection lasting longer than four hours A blood disorder, such as sickle cell anemia An inherited eye disease called retinitis pigmentosa Vision loss, or a problem with the nerve between your eyes and brain (optic nerve) Health conditions or factors that raise the risk of optic nerve problems, such as diabetes, high cholesterol, smoking, being older than 50, or having a “crowded disc,” which is something an eye doctor may see in an eye exam Pulmonary veno-occlusive disease, a condition where blood vessels in the lungs are blocked It is not known if or how sildenafil could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take sildenafil while breastfeeding. If you take sildenafil after you eat a high-fat meal, such as a burger and fries, it may take longer to start working. Your healthcare provider may recommend limiting or avoiding grapefruit while taking sildenafil. Grapefruit or grapefruit juice can raise sildenafil levels in your body, which can increase the risk of side effects. There are no known interactions between sildenafil and alcohol. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. In particular, make sure that you discuss if you are using any of the following before taking sildenafil. Tell your healthcare provider about all medicines that you take or have recently taken. This may not be a complete list of medicines that can interact with sildenafil. If you or someone else has used too much sildenafil, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222. For this use, sildenafil is used only when needed. Take it as your healthcare provider recommends, which is usually between 30 minutes to four hours before planned sexual activity. For this use, take sildenafil as your healthcare provider recommends, which is usually three times a day. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Ask your healthcare provider if you are unsure what to do after a missed dose. This survey is being conducted by the WebMD marketing sciences department. You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Sildenafil citrate promotes mobilization of hematopoietic stem cells (HSCs) in combination with AMD 3100 (Cat. Sildenafil citrate is sildenafil products over the counter also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris. The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. Tocris products are intended for laboratory research use only, unless stated otherwise.
Related/similar drugs
Sildenafil citrate is sildenafil products over the counter also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris. The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. Tocris products are intended for laboratory research use only, unless stated otherwise.
Allergy warning
The following data is based on the product molecular weight 666.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. Calculate the mass, volume, or concentration required for a solution. Calculate the dilution required to prepare a stock solution. References are publications that support the biological activity of the product. The following data is based on the product molecular weight 666.7.
Proper Use
A household spoon is not an accurate measuring device and may cause you to take the wrong dose. Ask your pharmacist to recommend an appropriate measuring device. Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if sildenafil is right for you. In particular, make sure that you discuss any of the following.
Raynaud's phenomenon
Tell your healthcare provider if you have any of the following. Heart problems, such as heart rhythm problems, chest pain, or heart failure Heart attack, stroke, or heart surgery within the past six months High blood pressure that is still too high despite taking medicines for it Peyronie's disease, or a penis with an abnormal curve or shape An erection lasting longer than four hours A blood disorder, such as sickle cell anemia An inherited eye disease called retinitis pigmentosa Vision loss, or a problem with the nerve between your eyes and brain (optic nerve) Health conditions or factors that raise the risk of optic nerve problems, such as diabetes, high cholesterol, smoking, being older than 50, or having a “crowded disc,” which is something an eye doctor may see in an eye exam Pulmonary veno-occlusive disease, a condition where blood vessels in the lungs are blocked It is not known if or how sildenafil could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take sildenafil while breastfeeding. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. Calculate the mass, volume, or concentration required for a solution. Calculate the dilution required to prepare a stock solution.
- Sildenafil citrate was approved by the FDA in 1998.
- Its discovery revolutionized the treatment of erectile dysfunction.
- The medication requires sexual stimulation to be effective.
- It is not an aphrodisiac; it facilitates natural response.
- Overdose symptoms may include severe hypotension.
- Recreational use of sildenafil without prescription is risky.
- Combining with alcohol can increase side effects.
- It should be stored at room temperature away from moisture.
References are publications that support the biological activity of the product. Ballard et al (1998) Effects of silde. Turko et al (1999) Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by silde. Ghofrani et al (2006) Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Smith-Berdan et al (2019) Viagra enables efficient, single-day hematopoietic stem cell mobilization.
What is sildenafil?
Keep sildenafil out of the reach of children. If you keep sildenafil oral liquid in a refrigerator, make sure to keep it away from children who also use the refrigerator. Sexual activity can put extra strain on your heart, which may be unsafe for people with certain health problems, such as a recent heart attack. Talk to your healthcare provider to see if your heart is strong enough for sex. If you feel chest pain, dizziness, or nausea during sex, stop and contact your healthcare provider right away.
Jet lag research
Sildenafil does not protect against sexually transmitted infections, including HIV. Sildenafil belongs to a group of medicines, known as phosphodiesterase-5 (PDE-5) inhibitors, which are used to treat erectile dysfunction or pulmonary arterial hypertension. You should not take more than one PDE-5 inhibitor medicine. Medicines in this group include avanafil (Stendra), sildenafil (Viagra, Revatio, and others), tadalafil (Cialis and others), and vardenafil (Levitra, Staxyn). Use an accurate measuring device to measure your dose of sildenafil oral liquid. If you know of a relevant reference for Sildenafil citrate, please let us know. Keywords: Sildenafil citrate, Sildenafil citrate supplier, phosphodiesterases, 5, PDE5, inhibitors, inhibits, orally, active, potent, HSC, hematopoietic, haematopoietic, stem, cells, mobilization, COVID-19, pulmonary, edema, Phosphodiesterases, Stem, Cell, Proliferation, Hematopoietic, Cells, 3784, Tocris Bioscience Citations are publications that use Tocris products. Vandendriessche et al (2013) The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems. Xiaofeng et al (2021) Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage. Cell Chem Biol 28 1669-1678.e5 PMID: 34166610 Do you know of a great paper that uses Sildenafil citrate from Tocris? There are currently no reviews for this product. Be the first to review Sildenafil citrate and earn rewards! $25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image Departments of Nephrology and Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India Received December 27, 2005; Accepted April 10, 2006; Published online May 24, 2006 Originally published online as doi:10.1053/j.ajkd.2006.04.061 on May 24, 2006. Support: Zydus Cadila provided placebo and sildenafil tablets. DOI: 10.1053/j.ajkd.2006.04.061 External LinkAlso available on ScienceDirect External Link ERECTILE DYSFUNCTION (ED) is the persistent inability to achieve a sustained erection sufficient for satisfactory sexual performance. The mental stress resulting from ED affects patients’ interactions with family and others.1 ED is observed frequently in patients with end-stage renal disease and patients on hemodialysis therapy, and the estimated prevalence is between 71% and 82% in these patients.2,3 Only up to 75% of these patients recover from ED after renal transplantation.4 ED also may occur in up to a third of patients receiving a double transplant with vascular anastomosis to the hypogastric artery because of reduced arterial flow to the penis.5 Treatment options for men with ED include psychosexual therapy, drug therapy, transurethral or intracavernosal therapy, treatment with vacuum constriction devices, and surgical treatment.6 Sildenafil citrate is a selective inhibitor of phosphodiesterase type 5, which is the predominant isozyme interacting with cyclic guanosine monophosphate in corpus cavernosum and results in increased smooth muscle relaxation and improved erection. Recently, sildenafil was shown to be an effective, safe, and well-tolerated drug for men with ED7 and end-stage renal disease and maintenance hemodialysis patients with ED.8-11 There are few either nonrandomized or uncontrolled studies on the use of sildenafil in renal allograft recipients.12-16 There have been no double-blind placebo-controlled studies with sildenafil in renal allograft recipients. The area under the curve (AUC) of cyclosporine before and after sildenafil therapy was not compared in any of these studies.12-16 Therefore, we conducted a randomized, double-blind, placebo-controlled, crossover study to establish the safety and efficacy of sildenafil in renal transplant recipients with ED. The study is designed as a randomized, double-blind, placebo-controlled, crossover trial. Inclusion criteria for patients were renal transplant recipients who: (1) had stable graft function in the last 6 months, (2) were 18 years and older, (3) had medically documented ED as defined by the National Institute of Health Consensus Panel,1 and (4) were in a stable relationship with a female partner in the last 6 months.
Overdose/Missed Dose
Be the first to review Sildenafil citrate and earn rewards! $25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image Departments of Nephrology and Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India Received December 27, 2005; Accepted April 10, 2006; Published online May 24, 2006 Originally published online as doi:10.1053/j.ajkd.2006.04.061 on May 24, 2006. Support: Zydus Cadila provided placebo and sildenafil tablets. DOI: 10.1053/j.ajkd.2006.04.061 External LinkAlso available on ScienceDirect External Link ERECTILE DYSFUNCTION (ED) is the persistent inability to achieve a sustained erection sufficient for satisfactory sexual performance. The mental stress resulting from ED affects patients’ interactions with family and others.1 ED is observed frequently in patients with end-stage renal disease and patients on hemodialysis therapy, and the estimated prevalence is between 71% and 82% in these patients.2,3 Only up to 75% of these patients recover from ED after renal transplantation.4 ED also may occur in up to a third of patients receiving a double transplant with vascular anastomosis to the hypogastric artery because of reduced arterial flow to the penis.5 Treatment options for men with ED include psychosexual therapy, drug therapy, transurethral or intracavernosal therapy, treatment with vacuum constriction devices, and surgical treatment.6 Sildenafil citrate is a selective inhibitor of phosphodiesterase type 5, which is the predominant isozyme interacting with cyclic guanosine monophosphate in corpus cavernosum and results in increased smooth muscle relaxation and improved erection.
Why it’s used
Recently, sildenafil was shown to be an effective, safe, and well-tolerated drug for men with ED7 and end-stage renal disease and maintenance hemodialysis patients with ED.8-11 There are few either nonrandomized or uncontrolled studies on the use of sildenafil in renal allograft recipients.12-16 There have been no double-blind placebo-controlled studies with sildenafil in renal allograft recipients. The area under the curve (AUC) of cyclosporine before and after sildenafil therapy was not compared in any of these studies.12-16 Therefore, we conducted a randomized, double-blind, placebo-controlled, crossover study to establish the safety and efficacy of sildenafil in renal transplant recipients with ED. The study is designed as a randomized, double-blind, placebo-controlled, crossover trial. Inclusion criteria for patients were renal transplant recipients who: (1) had stable graft function in the last 6 months, (2) were 18 years and older, (3) had medically documented ED as defined by the National Institute of Health Consensus Panel,1 and (4) were in a stable relationship with a female partner in the last 6 months. All patients were subjected to a detailed medical history and physical examination that included blood pressure, pulse rate, 12-lead electrocardiogram, cyclosporine A level by means of enzyme multiplied immunoassay method, and standard biochemistry (blood urea nitrogen, serum creatinine) and hematologic tests (hemoglobin, total and differential leukocyte count, and platelet count) at baseline and after each crossover. All patients were subjected to a detailed medical history and physical examination that included blood pressure, pulse rate, 12-lead electrocardiogram, cyclosporine A level by means of enzyme multiplied immunoassay method, and standard biochemistry (blood urea nitrogen, serum creatinine) and hematologic tests (hemoglobin, total and differential leukocyte count, and platelet count) at baseline and after each crossover.