How Sildenafil Oral Solution Works
This content is informational/educational and is not intended to treat or diagnose any disease or patient.
Why is this medication prescribed?
If it is almost time for your next dose, skip the missed dose and only take the next dose. Ask your healthcare provider if you are unsure what to do after a missed dose. This survey is being conducted by the WebMD marketing sciences department. Our friendly customer care team is standing by for support. This content is intended for counseling purposes only. No claims are made as to the safety or efficacy of mentioned preparations.
| Condition | Recommended Range | Notes |
|---|---|---|
| Temperature | 2°C to 25°C | Keep away from freezing or excessive heat |
| Light exposure | Store in opaque container | Protect from light |
| Humidity | Dry environment | Avoid moisture to prevent degradation |
| Shelf life | 24 months | Check expiry date before use |
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- Sildenafil oral solution is a liquid form of erectile dysfunction medication.
- It allows for easier swallowing compared to pills.
- Typically, it's used when oral tablets are unsuitable.
Use of them does not imply any affiliation with or endorsement by them.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 150mg | 60 + 4 Pills | 111.25€ 105.95€ | |
| Viagra Generic | 150mg | 90 + 6 Pills | 147.18€ 140.17€ | |
| Kamagra | 100mg | 360 + 6 Pills | 839.95€ 799.95€ | |
| Viagra Generic | 50mg | 30 + 4 Pills | 54.26€ 51.68€ | |
| Kamagra Polo | 100mg | 12 Pills | 60.21€ 57.34€ | |
| Viagra Generic | 150mg | 10 Pills | 36.73€ 34.98€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Kamagra Oral Jelly | 100mg | 220 + 18 Sachets | 662.24€ 630.70€ | |
| Viagra Generic | 200mg | 360 + 10 Pills | 481.98€ 459.03€ | |
| Viagra Generic | 50mg | 90 + 6 Pills | 107.37€ 102.26€ | |
| Viagra Generic | 200mg | 60 + 4 Pills | 125.19€ 119.23€ | |
| Kamagra Soft Tabs | 100mg | 180 + 8 Pills | 425.45€ 405.19€ |
Sildenafil (Revatio) is a medicine used to treat pulmonary arterial hypertension (PAH), a narrowing of the small blood vessels in the lungs that results in increased pressure. The condition can affect both adults and children.
Warnings & Precautions
If your nosebleed is severe or will not stop after applying pressure, get help right away. People who are allergic to any of the following should not take sildenafil. Any of the ingredients in the specific product dispensed Your pharmacist can tell you all of the ingredients in the specific sildenafil products they stock. Sildenafil should not be taken while you are using certain other medicines. Before taking sildenafil, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
5.2 Worsening Pulmonary Vascular Occlusive Disease
See the Interactions section for more details. Do not take sildenafil unless it has been prescribed to you by a healthcare provider. Do not share sildenafil with other people, even if they have the same condition as you. Keep sildenafil out of the reach of children. If you keep sildenafil oral liquid in a refrigerator, make sure to keep it away from children who also use the refrigerator.
Physicochemical Properties of Various Sildenafil-Loaded Drug Delivery Sytems
Sexual activity can put extra strain on your heart, which may be unsafe for people with certain health problems, such as a recent heart attack. Talk to your healthcare provider to see if your heart is strong enough for sex. If you feel chest pain, dizziness, or nausea during sex, stop and contact your healthcare provider right away. Sildenafil does not protect against sexually transmitted infections, including HIV. Sildenafil belongs to a group of medicines, known as phosphodiesterase-5 (PDE-5) inhibitors, which are used to treat erectile dysfunction or pulmonary arterial hypertension. Sildenafil is available as an intravenous infusion, a tablet, and as an oral liquid suspension (10 mg/mL) which is easier to use for children. The oral suspension comes with a 2 mL oral syringe that only has markings for 5 mg (0.5 mL) and 20 mg (2 mL) (Figure 1). This means that if a 10 mg dose is needed, a volume of sildenafil oral strips 1 mL will be needed to give the correct dose. Since there is not a 1 mL marking on the syringe, the medicine should be drawn up to the 0.5 mL mark twice to give the correct dose. Infants with PAH may need an even smaller dose (less than 0.5 mL) based on their weight. So, parents would not be able to measure the correct dose using the enclosed syringe. In a recent case, an infant was to receive a dose of sildenafil oral suspension 2.5 mg (0.25 mL) every 8 hours.
| Condition | Approved Dose | Typical Usage | Notes |
|---|---|---|---|
| Erectile Dysfunction | 20 mg-100 mg | Administer 30-60 min before activity | Dose depends on severity |
| Pulmonary Arterial Hypertension | 5 mg-20 mg | Usually 3 times daily | Under medical supervision |
| Raynaud's Phenomenon | Off-label | 20 mg before episodes | Not officially approved |
When the pharmacy dispensed the medicine, the label included instructions to administer 0.25 mL. However, the pharmacy did not remove the enclosed syringe which could not measure 0.25 mL. At home, the parents used the mg dose number (2.5) to measure the medicine. It is possible that the syringe contributed to the confusion since there are no markings for 0.25 mL. The parents probably used the syringe twice to administer 2.5 mL (one 0.5 mL dose plus one 2 mL dose). The error was not discovered until the parents requested a refill which was too early based on the volume originally dispensed. Fortunately, the infant did not have any adverse effects from the higher dose of medicine. Here's what you can do: When picking up sildenafil oral suspension from your pharmacy, ask to speak to the pharmacist. Open the package in front of the pharmacist and ask how to measure a dose. If the enclosed syringe does not have markings to measure the dose needed, ask the pharmacist for an appropriate size syringe.
- The solution is usually flavored for better taste.
- Dosing involves measuring with a provided syringe or dropper.
- It offers rapid absorption into the bloodstream.
Then ask the pharmacist to show you how to measure a dose using the syringe.
- It is not recommended for use in children or women.
- Overdose symptoms include dizziness, vision changes, and prolonged erections.
- Seek urgent medical help in case of overdose.
For example, in the case described above, since the dose was less than 1 mL, the pharmacy should have given the parents a 1 mL oral syringe. The pharmacist should have shown them what marking to use to measure the correct dose (0.25 mL). Finally, you should also repeat back, and show the pharmacist how you will measure a dose using the device. Sildenafil citrate 25-mg tabletsa were used to prepare the suspensions.
| Condition | Risk Factors | Alternative Recommendations |
|---|---|---|
| Use with nitrates | Severe hypotension | Avoid concomitant use |
| Severe hepatic impairment | Altered drug metabolism | Dose adjustment or alternative therapy |
| Cardiovascular instability | Risk of adverse events | Medical evaluation required |
| Retinitis pigmentosa | Potential retinal toxicity | Consult ophthalmologist |
The tablets were ground to fine powder using a mortar and pestle and combined with a 1:1 mixture of methyl-cellulose 1%b (Appendix A) and Simple Syrup, NF,c or a 1:1 mixture of Ora-Plusd and Ora-Sweete (Appendix B). The nominal concentration of sildenafil citrate in each suspension was 2.5 mg/mL. Approximately 30 mL of each suspension was transferred to 10 2-oz amber plastic prescription bottles.f Five plastic bottles of each suspension were stored at 4 ºC in a refrigerator,g and five were stored at 25 ºC in a temperature-controlled water bath.h The samples were taken after the bottles were shaken on a wrist-action shaker for 10 minutes and then allowed to stand for 2 minutes. The bottles were then gently inverted three times and the caps removed; the samples were withdrawn from the center of the bottles at midlevel of liquid. Three 500-µL samples were collected from each bottle on days 0, 7, 14, 28, 42, 56, 70, and 91 after preparation and analyzed in duplicate by a high-performance liquid chromatographic (HPLC) method modified and validated in our laboratory.
Side Effects
You should not take more than one PDE-5 inhibitor medicine. Medicines in this group include avanafil (Stendra), sildenafil (Viagra, Revatio, and others), tadalafil (Cialis and others), and vardenafil (Levitra, Staxyn). Use an accurate measuring device to measure your dose of sildenafil oral liquid. A household spoon is not an accurate measuring device and may cause you to take the wrong dose. Ask your pharmacist to recommend an appropriate measuring device.
What should I do if I miss a dose of sildenafil?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if sildenafil is right for you. In particular, make sure that you discuss any of the following. Tell your healthcare provider if you have any of the following. Heart problems, such as heart rhythm problems, chest pain, or heart failure Heart attack, stroke, or heart surgery within the past six months High blood pressure that is still too high despite taking medicines for it Peyronie's disease, or a penis with an abnormal curve or shape An erection lasting longer than four hours A blood disorder, such as sickle cell anemia An inherited eye disease called retinitis pigmentosa Vision loss, or a problem with the nerve between your eyes and brain (optic nerve) Health conditions or factors that raise the risk of optic nerve problems, such as diabetes, high cholesterol, smoking, being older than 50, or having a “crowded disc,” which is something an eye doctor may see in an eye exam Pulmonary veno-occlusive disease, a condition where blood vessels in the lungs are blocked It is not known if or how sildenafil could affect pregnancy or harm an unborn baby.
Serious side effects
Tell your healthcare provider if you are or plan to become pregnant. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take sildenafil while breastfeeding. If you take sildenafil after you eat a high-fat meal, such as a burger and fries, it may take longer to start working. Your healthcare provider may recommend limiting or avoiding grapefruit while taking sildenafil. The pH of each solution was measured on each study day. All solutions were observed for any changes in color and turbidity using black and white backgrounds.
- The cost of sildenafil oral solution varies depending on brand and pharmacy.
- Generic versions are typically less expensive.
- Availability might be limited in some regions or countries.
The HPLC instrumentation consisted of a pump,i an autosampler,j a variable-wavelength ultraviolet-light detector,k a chromatography data system,l a C18 column,m a digital pH meter,n a wrist-action shaker,o and a Vortex mixer.p The chemicals and reagents, including acetonitrile,q methanol,r and buffer solutions pH 7.00,s 4.00,t and 10.00,u were American Chemical Society or analytical grade.
8. Use In Specific Populations
Grapefruit or grapefruit juice can raise sildenafil levels in your body, which can increase the risk of side effects. There are no known interactions between sildenafil and alcohol. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. In particular, make sure that you discuss if you are using any of the following sildenafil 25 mg tablets before taking sildenafil. Tell your healthcare provider about all medicines that you take or have recently taken.
Drug Interactions
This may not be a complete list of medicines that can interact with sildenafil. If you or someone else has used too much sildenafil, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222. For this use, sildenafil is used only when needed. Take it as your healthcare provider recommends, which is usually between 30 minutes to four hours before planned sexual activity. For this use, take sildenafil as your healthcare provider recommends, which is usually three times a day.